Preheat oven to 400°F (200°C). Unroll pie crust into a 9-inch deep-dish pie plate, crimp edges. Blind bake with pie weights for 8 minutes. Remove weights and lower oven to 375°F (190°C).

In a large skillet over medium-high heat, brown ground beef, Italian sausage, and onion until meat is cooked through (about 8 mins). Add garlic in the last minute.

Drain all excess grease from the skillet. Return to low heat and stir in pizza sauce, Italian seasoning, salt, and pepper. Simmer for 2 minutes, then remove from heat.

Sprinkle 1/4 cup of mozzarella cheese over the bottom of the pre-baked crust.

Spread the meat and sauce mixture evenly into the crust.

Top with the remaining mozzarella and Parmesan cheese. Arrange pepperoni slices on top and sprinkle with dried oregano.

Bake for 20-25 minutes until the crust is golden, cheese is bubbly, and pepperoni is crispy.

Let the pie rest for 10-15 minutes before slicing and serving hot.